KLOW: 80 mg ($85)
Overview
KLOW is an informal market name for a four-component blend, most commonly described as the GLOW: 70 mg combination along with 10 mg of KPV, an anti-inflammatory peptide. The designation is not standardized and composition varies by supplier.
In plain terms
This is the largest of the blends by both component count and total mass. It pairs the copper-peptide and tissue-repair components of the GLOW combination with KPV, a very short anti-inflammatory fragment.
KPV is just three amino acids — lysine, proline, valine — taken from the tail end of α-melanocyte stimulating hormone. Researchers study that fragment separately because it appears to retain the parent hormone's anti-inflammatory activity while dropping its effect on pigmentation. The general caution that applies to every blend in this category applies here with the most force: four constituents in one vial means four separate literatures and no published work on how they behave together.
Technical description
GHK-Cu is the copper(II) complex of glycyl-L-histidyl-L-lysine (MW 401.9), reported to influence collagen and glycosaminoglycan synthesis and metalloproteinase expression in fibroblast systems. BPC-157 is a pentadecapeptide (MW 1419.5) with no conclusively identified cognate receptor. TB-500 is a thymosin β4 actin-binding domain fragment reported to influence actin dynamics and cell migration.
KPV is the C-terminal tripeptide of α-MSH (Lys-Pro-Val, MW 342.4), reported to inhibit NF-κB nuclear translocation and downregulate pro-inflammatory cytokine expression, with negligible melanocortin receptor agonism. No published pharmacological characterization exists for these four constituents administered in combination, including possible interactions between the copper complex and the co-formulated peptides.
- Type
- Four-component blend
- Component 1
- GHK-Cu — 50 mg
- Component 2
- BPC-157 — 10 mg
- Component 3
- TB-500 (thymosin β4 fragment) — 10 mg
- Component 4
- KPV (α-MSH 11–13) — 10 mg
- Total mass
- 80 mg
- Appearance
- Blue to blue-tinted lyophilized powder
- Storage
- Lyophilized: −20 °C, protected from light. Reconstituted: 2–8 °C.
Regulatory status
No constituent is an FDA-approved drug for any therapeutic indication. GHK-Cu is used as a cosmetic ingredient in topical formulations. BPC-157 was placed in Category 2 of the FDA's bulk drug substances review in 2023, and both BPC-157 and TB-500 are prohibited by the World Anti-Doping Agency. No combination product containing these substances holds marketing authorization in any jurisdiction. Material supplied for laboratory research is not manufactured, tested, or released under pharmaceutical or cosmetic-grade standards.